Acid phosphatase { ACP} TEST

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Acid phosphatase { ACP} TEST

Definition :

– ACP is an enzyme located primarily in the prostate gland and prostate secretion, smaller amount also present in spleen bone marrow, RBC, platelets , liver, and kidney .

– 2 isoform of ACP include prostatic (PAP), and erythrocytic ACP used in prognosis of prostate cancer.

-It is less specific than (PSA).

-ACP acts optimally below PH 6.0 to split off phosphate group from organic phosphate ester.

Clinical significance:

Increased in : 1-2 days after prostate surgery or biopsy, after prostate manipulation or catheterization, prostatitis, prostate hypertrophy, and prostate infarction. Bone fracture, bone cancer with metastasis, {ITP}, MM and thrombocytosis.

Methodology:

kinetic / PNP

Normal range:

2.7-10.7 U/L

Limitation:

-Prostatic massage or urinary catheterization causes elevation of ACP.

– ACP help in diagnosis of advanced cancer.

PAP is replaced by PSA due to its sensitivity to prostate cancer.  –

– PAP is present in vaginal secretion in low conc <5 U/L; the presence of > 50 U/L will cofirmly mean recent coitus and useful for testing the sexual assault victims.

Acid phosphatase { ACP} TEST

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