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Antistreptolysin O Titer ( ASOT ) Test

Antistreptolysin O Titer ( ASOT ) Test

Antistreptolysin O (ASO) is an antibody targeted against streptolysin O, a toxic enzyme produced by group A Streptococcusbacteria. ASO and anti-DNase B are the most common of several antibodies that are produced by the body’s immune system in response to a strep infection with group A Streptococcus. This test measures the amount of ASO in the blood.

The ASO test is primarily used to help determine whether a recent strep infection with group A Streptococcus:

• Is the cause of a person’s or glomerulonephritis, a form of kidney disease
• Caused rheumatic fever in a person with signs and symptoms

The test may be ordered by itself or along with an anti-DNase B, another test used to detect recent strep infections.

In most cases, strep infections are identified and treated with antibiotics and the infections resolve. In cases where they do not cause identifiable symptoms and/or go untreated, however, complications (sequelae), namely rheumatic fever and glomerulonephritis, can develop in some people, especially young children. The test, therefore, is ordered if a person presents with symptoms suggesting rheumatic fever or glomerulonephritis and has had a recent history of sore throat or a confirmed streptococcal infection.

Some symptoms of rheumatic fever may include:

• Fever
• Joint swelling and pain in more than one joint, especially in the ankles, knees, elbows and wrists, sometimes moving from one joint to another
• Small, painless nodules under the skin
• Rapid, jerky movements (Sydenham’s chorea)
• Skin rash
• Sometimes the heart can become inflamed (carditis); this may not produce any symptoms but also may lead to shortness of breath, heart palpitations, or chest pain.

sample :

Whole blood.

-ASO antibodies are produced about a week to a month after an initial strep infection. The amount of ASO antibody (titer) peaks at about 3 to 5 weeks after the illness and then tapers off but may remain detectable for several months after the strep infection has resolved.

-An elevated titer of antibody (positive ASO) or an ASO titer that is rising means that it is likely that the person tested has had a recent strep infection. ASO titers that are initially high and then decline suggest that an infection has occurred and may be resolving.

Antistreptolysin O Titer ( ASOT ) Test

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