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AST/GOT Test

AST/GOT Test

Aspartate aminotransferase (glutamate oxaloacetate transaminase) belongs

to the group of transaminases, which catalyze the conversion of aminoacids to the corresponding α-keto acids via the transfer of amino groups;

they also catalyze the reverse process. AST is commonly found in human

tissue.

Although heart muscle is found to have the most activity of the

enzyme, significant activity has also been seen in the brain, liver, gastric

mucosa, adipose tissue, skeletal muscles, and kidneys. AST is present in

both cytoplasm and mitochondria of cells.

In cases involving mild tissue injury, the predominant form of AST is that from the cytoplasm, with a smaller amount coming from the mitochondria. Severe tissue damage results in more of the mitochondrial enzyme being released. Elevated AST levels are found in hepatopathies, muscular dystrophy, and damage tointernal organs.

Increased levels of AST however are generally a result of liver disease associated with some degree of hepatic necrosis such as cirrhosis, carcinoma, viral or toxic hepatitis, and obstructive jaundice.

Following a myocardial infarction, serum levels of AST are elevated and

reach a peak 48 to 60 hours after onset.

SPECIMEN:

Serum, EDTA or heparinized plasma. Avoid hemolysis

EXPECTED VALUES:

AST/GOT Test

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