Cholinesterase {CHE} test

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Cholinesterase {CHE} test

Cholinesterase {CHE} test

Definition :

– CHE is an enzyme synthesized by liver and distributed along the body It hydrolyses acetylcholine and succinylcholine.

– This enzyme activity is inhibited reversibly by carbamate insecticides and irreversibly  organophosphorus insecticides so this test is most interest clinically in the detection of possible insecticide poisoning.

Clinical significance:

Increased in :Type IV hyperlipoproteinemia, nephrosis, obesity with DM , and breast cancer. –

– Decreased in: organophosphorus insecticide poisoning, hepatitis cirrhosis, hepatoma, anemia, MI and post-surgery.

Order the test:

emergency room, intensive care unit, internist doctors.

Methodology :

Kinetic / butyrylthiocholine

Normal range:

4900-11900 U/L

Limitation:

CHE decrease in pregnancy by 20%.-

– Some drugs are reduced the result like: anabolic steroids, estrogens, testosterone and radio graphic agents .

Cholinesterase {CHE} test

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