Gamma glutamyltransferase {GGT} TEST

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Gamma glutamyltransferase {GGT} TEST

Gamma glutamyltransferase {GGT} TEST

Definition :-

– GGT is a biliary excretory enzyme that catalyze the transfer of glutamyl group from peptide to another , across cellular membrane.

– It is found in liver , kidney , pancreas , brain , heart , salivary & prostate gland.It is useful to distinguish the liver disease , hepatocellular or biliary obstruction.

-It also help to differentiate ALP from bone or biliary tree.

Clinical significance:-

– Increased in :- Obstructive liver disease and less increase in cirrhosis, inflammation of liver, renal transplant, hyperthyroidism , DM , pancereatitis ,  CHF , MI , and SLE.

-Decreased in :- hypothyroidism.

Prespecimen processing :-

 Fasting 8 hours

Methodology:-

 Kinetic /L- glutamyl-p-nitroanilide.

Guiding Reference Value:

     M        11- 49 U/L

     F         7 – 32  U/L

Limitation :-

– GGT is more sensitive indicator of liver diseases than ALP especially in children and early-risk drinkers.

– Some drugs cause elevation of GGT levels include :- cephalosporin , estrogen , ethanol , phyntoin , and phenobarbital.

– And some drugs reduce the levels such as ; Ascorbic acid.

Gamma glutamyltransferase {GGT} TEST

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