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Protime /Prothrombin(PT)

Protime /Prothrombin(PT)

• Used to monitor oral anticoagulant therapy (Warfarin / Coumadin).
• When a patient who is not taking anti-coagulant drugs has signs or symptoms of a bleeding disorder
• When a patient is to undergo an invasive medical procedure, such as surgery, to ensure normal clotting ability.

Clinicaly:-

• The prothrombin time is therefore the time required for the plasma to clot after an excess of thromboplastin and an optimal concentration of calcium have been added.
• The PT measures functional activity of the extrinsic and common pathways.
• The PT evaluates patients suspected of having an inherited or acquired deficiency in these pathways.

       Sample :

• Blood in sodium chloride ( 1: 9 ).

       Normal range :

• The normal values for the prothrombin time range from 10.0 to 13.0 seconds.
• Increase means :
• An elevated prothrombin time may indicate the presence of
• Vitamin K deficiency,
• DIC,
• liver disease,
• Presence of FSP’s.
• a deficiency in one or more of the following factors:
• Factor I (Fibrinogen)
• Factor II (Prothrombin)
• Factor V (Proaccelerin, Labile Factor)
• Factor VII (Proconvertin, Stable Factor)
• Factor X (Stuart-Prower Factor)
• Factor XIII (Fibrin Stabilizing Factor)

  Protime /Prothrombin(PT)

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